Tramadol
نویسندگان
چکیده
منابع مشابه
PharmGKB summary: tramadol pathway.
Departments of Genetics, Bioengineering, Stanford University, Stanford, California, USA, Department of Anaesthesiology and Pain Medicine, Inselspital, Department of Clinical Research, University of Bern, Bern, Switzerland and Institute of Clinical Pharmacology, University Medical Center, Göttingen, Germany Correspondence to Teri E. Klein, PhD, Department of Genetics, Stanford University Medical...
متن کاملAtipik opioid analjezik: Tramadol
Tramadol, a centrally acting analgesic, consists of two enantiomers, both of which contribute to analgesic activity via different mechanisms. (+) Tramadol and the metabolite (+) -Odesmethyl-tramadol (M1) are agonists of the mu opioid receptor. (+) Tramadol also stimulates presinaptic release of serotonin and inhibits serotonin reuptake weheres (-) tramadol inhibits norepinephrine reuptake. Thus...
متن کاملPsychosis following Tramadol Withdrawal
BACKGROUND Tramadol is a centrally acting opioid analgesic used to treat moderate to sever pain. It has more advantage and less opioid adverse effects than conventional opioid analgesia. CASE REPORT This article reports a patient with tramadol dependency that had psychosis after tramadol withdrawal. CONCLUSION By the increase of tramadol usage for relief of chronic pain, tramadol abuse and ...
متن کاملRemifentanil and tramadol.
The lack of analgesic efficacy limits tramadol as a sole agent to treat severe pain after surgery. However, it has a relative lack of respiratory depressant and constipating effects compared with morphine and codeine, and does not share the propensity of nonsteroidal anti-inflammatory drugs to provoke asthma, gastrointestinal mucosal damage and renal impairment. It may well have a place in the ...
متن کاملBiomimetic synthesis of Tramadol.
Tramadol has recently been isolated from the roots and bark of Nauclea latifolia. A plausible biosynthetic pathway has been proposed and the product-precursor relationship has been probed by (13)C position-specific isotope analysis. By further exploring this pathway, we demonstrate that a key step of the proposed pathway can be achieved using mild conditions that mimic in vivo catalysis.
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ژورنال
عنوان ژورنال: Canadian Medical Association Journal
سال: 2013
ISSN: 0820-3946,1488-2329
DOI: 10.1503/cmaj.121592